I agree that OU would have find it more difficult to beat WVU and Louisville, than our usual W in hoops when we played CU and Nebraska. But you may be surprised to learn that OU's series record against Louisville is 3-1, and it's 1-1 against WVU. We beat the Mountaineers on a "neutral" West Virginia site in our last game with them in 2008, and then lost by a bunch to the Cardinals in the NCAA tourney that year.
The upside, of course, is that adding those two schools to the Big 12 Conference would increase our RPI in basketball and football, as well as improve our in-conference schedule in both sports. But with the Big East moving quickly to up the exit fee to keep member schools from going elsewhere, I doubt if either of those schools will be a candidate for the Big 12 now.